2 the drug against high blood pressure
2 the drug against high blood pressure

Ang presyon ng dugo ay isa sa mga pangunahing indikasyon ng kalusugan, na hindi lamang sumasalamin sa puso at sistema ng sirkulasyon, kundi pati na rin sa aktibidad ng mga bato, mga organo ng endokrin, paggawa ng dugo, at ng sistema ng nerbiyos. Kaya naman, walang isang unibersal na gamot laban sa mataas na presyon ng dugo. Hindi ka basta basta puwedeng pumunta sa botika at magtanong ng 'tableta para sa presyon,' kasi agad na tatanungin ng parmasyutiko – anong gamot ang nireseta sa iyo ng doktor?
ЧИТАТЬ ДАЛЕЕ ...
A drug against hypertension: mechanism of action and clinical application of LisinoprilHypertension medical Arterial hypertension referred to, constitute a worldwide health problem that is associated with an increased risk for cardiovascular disease, stroke, and kidney damage. An effective pharmacotherapy plays a Central role in the long-term control of this condition. A proven drug in this indication Lisinopril, a representative of ACE inhibitors (Angiotensin‑Converting‑Enzyme inhibitor) is.Mechanism of actionLisinopril works by selective inhibition of the Angiotensin‑converting enzyme (ACE), for the conversion of Angiotensin I to the vasoconstrictor Peptide Angiotensin II is responsible. Through the inhibition of ACE, the following physiological effects are triggered:Reduction of the production of Angiotensin II → vasodilation, and hence the reduction of peripheral vascular resistance;Decrease in the aldosterone distribution → reduced sodium and water retention in the body;Increase in Kinins (e.g., Bradykinin) → additional vasodilatory effect.The us results in a sustained reduction in systolic and diastolic blood pressure.PharmacokineticsLisinopril is taken orally has a bioavailability of about 25%-30%. It is not metabolised and is excreted unchanged via the kidney. The half-life is approximately 12 hours, which allows for a single daily dose.Clinical trials and effectivenessSeveral randomized controlled trials (RCTs) to confirm the efficacy of Lisinopril in the treatment of Arterial hypertension. In a large multicentre study (n = 1 200) showed in patients with moderate to severe hypertension results in an average reduction in blood pressure by 18.2/a 10.4 mmHg after 12 weeks of therapy with 20 mg of Lisinopril daily as compared to the placebo group (2,1/1.3 mmHg).Side effectsThe most common side effects:dry cough (about 5%-10% of patients);Hyperkalemia;Hypotension, especially after the first dose;Dizziness and headache;in rare cases, angioedema.Indications and dosageIn addition to Arterial hypertension Lisinopril is also used to treat:Congestive heart failure;after a myocardial infarction (for the improvement of survival rate)approved.The usual starting dose for hypertension is 10 mg once daily, increased if necessary to 40 mg.ConclusionLisinopril is an effective and well-studied drug for the treatment of Arterial hypertension with a transparent mechanism of action. The clinical data support its role as a First‑Line treatment in many guidelines. Despite the potential side effects, it offers a favorable risk‑Benefit profile and contributes to the reduction of cardiovascular complications.
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