Monotherapy for hypertension

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Monotherapy for hypertension



Monotherapy for hypertension


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Monotherapy for hypertension: The role of SartansHigh blood pressure, known medically as hypertension referred to, is one of the most common health problems of modern society. According to studies, millions of people worldwide suffer from this disease, which is not covered if you need to — to serious complications such as heart attack, stroke, or kidney damage can result. An effective reduction in blood pressure is, therefore, essential. In recent years, the mono-therapy with Sartans has proven to be a promising approach established.What Sartans are?Sartans, also known as Angiotensin‑II‑receptor blocker (in short ARB) are known, belong to a class of drugs that are purposefully lowering the blood pressure. Their effect is due to the fact that you are not blocking the binding of Angiotensin II to its receptors in the body. Angiotensin II is a powerful vasokonstriktives peptides — it constricts blood vessels and leads to an increase in blood pressure. The inhibition of this effect of Sartans for a relaxation of the vessel walls and thus a reduction in blood pressure.Among the most famous representatives of this group:Losartan,Valsartan,Candesartan,Irbesartan.Why Mono-Therapy?The idea of mono-therapy is simple and clear treatment strategy: Instead of multiple medication is first prescribed a single drug in adjusted doses. This has several advantages:Easier Ingestion. Patients take a drug, what are the Compliance (adherence to Therapy) increases.Reduced risk of side effects. The less medication, the lower the risk of adverse interactions.Cost-efficiency. A single therapy is often more economical as a combination therapy.Makes It Easier To Monitor. The doctor and the Patient can control the effect and tolerability of the preparation the better.Studies and resultsNumerous clinical studies confirm the effectiveness of Sartans in the monotherapy treatment of high blood pressure. Time was, for example, a long study, Losartan, in patients with moderate hypertension, a significant reduction in blood pressure within 8-12 weeks could be achieved. Also, Valsartan has been shown in studies to be safe and effective, particularly in patients who cannot tolerate ACE inhibitors because of side effects (such as cough).Advantages of Sartans compared to other drugsCompared to other blood pressure Sartans have some special advantages:You can rarely cause a cough (a common Problem with ACE‑inhibitors).You will have a good impact on older patients.They provide additional protection for the heart and kidneys, particularly in diabetic patients is of great importance.Their effect is long-lasting, so that often a single daily dose is sufficient.Challenges and limitationsDespite its advantages, the mono-therapy is not with Sartans for each patient the optimal solution. In the case of severe hypertension, or in the Presence of other risk factors (such as Diabetes, congestive heart failure) can be a combination therapy with diuretics or calcium antagonists is required. In addition, patients should regularly measure blood pressure and medical care, to identify potential side-effects at an early stage.ConclusionThe mono-therapy with Sartans is a modern, safe and effective approach for the treatment of high blood pressure. It offers patients a simple, well-tolerated and sustainable way to keep your blood pressure in the healthy range. Nevertheless, an individual examination by the physician is essential to the therapy can be optimally adapted to the needs and Health of the Individual.Would you like me to make a certain section in more detail, or to add more information about an aspect?

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