Atherosclerosis of the heart vascular diseases

Minsan, dinadagdagan ng doktor ang base na therapy (mga gamot na kailangang inumin araw-araw) ng mga gamot na iniinom kapag may krisis, kapag ang presyon ay sobrang taas at biglang tumaas. At ang dosis ay pinipili rin nang napaka-indibidwal. Kaya imposible na sabihin kung alin ang pinakamahusay na gamot sa presyon, sa bawat kaso ay magkakaroon ng sariling kombinasyon na bagay sa iyo.

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Atherosclerosis as a cause of cardiovascular diseaseAtherosclerosis, also known as vascular calcification referred to, is one of the most important causes of cardiovascular disease (CVD) in industrialized countries. This chronic disease is characterized by a progressive change in the vessel walls, in particular, of the arteries, which leads to a stiffening and narrowing of the vessel lumen.PathophysiologyThe core process of atherosclerosis, the formation of atherosclerosis‑Placken (Atheromas) is on the inside of the artery walls. The process typically begins with damage to the endothelium — the innermost cell layer of the blood vessels. Factors such as high blood pressure (hypertension), high concentrations of low-density Lipoprotein (LDL, bad cholesterol), Smoking, and Diabetes mellitus can cause this injury.After the damage to LDL particles to penetrate into the vessel wall and become oxidized. This triggers a local inflammatory reaction: monocytes migrate into the vessel wall, in order to differentiate to macrophages and oxidized LDL. By Overloading it with lipids, so-called foam cells, which form the core of the early Plaque arise.With time, collagen, calcium, and other substances are deposited in the area of the Plaque. The Plaque grows and narrows the vessel lumen, what is the blood supply restricting the supplied organs. A particularly dangerous complication is the instability of the Plaque: In case of a rupture of the plaque ceiling, it can lead to thrombus formation (blood clot), which can occlude the vessel quickly and completely.Clinical effects on the cardiovascular systemThe hand-ment of atherosclerosis varies depending on the affected artery:Coronary arteries (coronary arteries): narrowing lead to a reduced oxygen supply to the heart muscle (the myocardium of ischemia). Symptoms may include Angina pectoris (chest pain at the time of load). A complete closure caused by a myocardial infarction.Cerebral vessels Atherosclerotic changes in the arteries of the brain, the risk for a stroke (apoplexy) increase as a result of thrombosis or embolism.Peripheral arteries: in Particular, the leg arteries are affected (peripheral arterial disease, pad). A typical Symptom is claudication (intermittent Klaudikation) is — calf cramps when walking, the decay stay again.Aorta: aneurysms (Bulges) of the Aorta, especially of the abdominal aortic section, are often due to atherosclerotic processes and represent the risk of a tear (rupture) a life-threatening Situation.Risk factorsOne distinguishes between modifiable and non-modifiable risk factors:Non-modifiable: age, male gender, family history.Modifiable: hypertension, hyperlipidemia (elevated cholesterol), Diabetes mellitus, Smoking, Overweight/obesity, lack of physical activity, unhealthy diet.Prevention and therapyEffective prevention of cardiovascular disease due to atherosclerosis is based on the influence of modifiable risk factors:Style changes: Smoking cessation, healthy diet (e.g., Mediterranean diet), regular physical activity, weight reduction in Overweight life.Drug Therapy:Cholesterol-lowering drugs (statins) to reduce the levels of LDL‑cholesterol;Blood pressure lowering in hypertension;Hypoglycemic agents in Diabetes mellitus;antiplatelet drugs (e.g. aspirin) to prevent thrombus.Interventional and surgical procedures: In the case of advanced narrowing of the procedures such as balloon dilatation with stent implantation (PTCA) or Bypass surgery are used.SummaryAtherosclerosis is a multifactorial, chronic process that forms the basis for most of the cardiovascular diseases. A comprehensive understanding of the pathophysiology and the risk factors is essential for the Primary and secondary prevention. Through a combined strategy of health-promoting life-style, and goal-directed medical therapy, the incidence and risk of complications can be significantly reduced.

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